YW1128 - CAS 2131223-64-6

SKU: orb611984

Description

YW1128 is an inhibitor of Wnt/β-catenin signaling with an IC50 value of 4.1 nM in a reporter assay

Research Area

Product Categories/Products/Small Molecules,Product Categories/Products/Small Molecules/Inhibitors

Images & Validation

−

Item 1 of 1

Application Notes

It decreases protein levels of β-catenin in the presence of the GSK3β inhibitor lithium chloride and increases protein levels of Axin1 in HEK293 cells. YW1128 decreases lipid accumulation and the expression of gluconeogenic and lipogenic genes in Huh7 cells. It decreases the hepatic expression of Wnt target genes, improves glucose tolerance, and prevents body weight increases and hepatic lipid accumulation in mice fed a high-fat diet, but not mice fed normal chow, when administered at a dose of 40 mg/kg every other day for 11 weeks

Key Properties

−

CAS Number	2131223-64-6
MW	343.4
Purity	> 98%
Formula	C₂₀H₁₇N₅O
SMILES	O=C(C1=C(C)N(C2=C(C)C=CC=C2)N=N1)NC3=CC=C(C=CC=C4)C4=N3

Storage & Handling

−

Storage	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Protocol Information

Find More Protocols

YW1128 - CAS 2131223-64-6

Description

Research Area

Images & Validation

Key Properties

Storage & Handling

Quality Guarantee

Protocol Information

Available Sizes

Email

UK Office

US Office

CN Office

Distributors