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PROTAC SMARCA2 degrader-17

SKU: orb2665118

Description

PROTAC SMARCA2 degrader-17 (compound I-290) is a targeted PROTAC degrader for SMARCA2. It exhibits a DC50 of less than 100 nM and achieves a maximum degradation efficiency (Dmax%) of over 90% in A549 cells after 24 hours of treatment.

Research Area

,PROTAC

Images & Validation

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Key Properties

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CAS Number2568276-43-5
MW797.95
Purity98.00%
FormulaC44H51N11O4
SMILESO=C1NC(=O)C(N2C(=O)N(C3=CC(=CC=C32)C4CCC(N5CCC(C6=CN=C(N=C6)N7C8CN(C=9C=C(N=NC9N)C%10=CC=CC=C%10O)CC7CC8)CC5)CC4)C)CC1

Storage & Handling

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Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Key Properties

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No computed properties available.

Protocol Information