Luminespib

SKU: orb1306830

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Description

Luminespib

Research Area

Product Categories/Products/Small Molecules,Apoptosis|||Autophagy|||Metabolism|||Cytoskeletal Signaling

Images & Validation

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Item 1 of 1

Key Properties

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CAS Number	747412-49-3
MW	465.54
Purity	99.26%
Formula	C₂₆H₃₁N₃O₅
SMILES	CCNC(=O)c1noc(c1-c1ccc(CN2CCOCC2)cc1)-c1cc(C(C)C)c(O)cc1O

Bioactivity

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Target IC50	HSP90 α:7.8 nM (cell free)\|TRAP1:85 nM\|HSP90 β:21 nM (cell free)\|GRP94:535 nM
In Vivo	METHODS: To study the effect on H. pylori-associated gastritis, Patchouli alcohol (5-20 mg/kg) was administered orally to H. pylori infected mice once daily for two weeks. RESULTS: Patchouli alcohol treatment increased SH-NP content and CAT activity and significantly protected the gastric mucosa from H. pylori-induced damage.
In Vitro	METHODS: H. pylori infected GES-1 cells were treated with Patchouli alcohol (5-20 µg/mL) for 24 h. Apoptosis was detected by flow cytometry. RESULTS: Patchouli alcohol treatment significantly reduced H. pylori-induced apoptosis. METHODS: H. pylori-infected GES-1 cells were treated with Patchouli alcohol (5-20 µg/mL) for 24 h. Cytokine levels were measured by ELISA. RESULTS: Treatment with 5-20 µg/mL Patchouli alcohol significantly reduced the production of TNF-α and MCP-1.
Cell Research	Cell lines were grown in DMEM/10% FCS, 2 mmol/L glutamine, and nonessential amino acids in a humidified atmosphere of 5% CO2 in air. All lines were free of Mycoplasma. Cell proliferation was determined using the sulforhodamine B (SRB) assay for tumor cells and prostate epithelial cells, the WST-1 assay for MCF10A and HB119, or an alkaline phosphatase assay for HUVEC and HDMEC. GI50 was the compound concentration inhibiting cell proliferation by 50% compared with vehicle controls. Cell cycle analysis was as described. Active caspase-3/7 was measured using a homogenous caspase assay kit .
Animal Research	In vivo, pharmacokinetic studies in female NCr athymic mice bearing WM266.4 human melanoma xenografts were essentially as described. NVP-AUY922 was dissolved in DMSO and diluted in sterile saline/Tween 20. A single dose of 50 mg/kg NVP-AUY922 was given i.v. or i.p. and groups of three animals were taken at intervals for pharmacokinetic analyses .

Storage & Handling

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Storage	-20°C
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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AUY922, NVP-AUY922, VER-52296

Quality Guarantee

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Compound Identifiers

PubChem CID

135539077 ↗

Key Properties

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No computed properties available.

Protocol Information

Find More Protocols

CAS Number:	[747412-49-3]
MW:	465.541
Formula:	C₂₆H₃₁N₃O₅

Purity:	> 98%
CAS Number:	[747412-49-3]
MW:	465.54
Formula:	C₂₆H₃₁N₃O₅

Purity:	> 99%
CAS Number:	747412-49-3
MW:	465.5
Formula:	C₂₆H₃₁N₃O₅

Purity:	0.98
CAS Number:	747412-64-2
MW:	479.57
Formula:	C₂₈H₃₇N₃O₈S

Luminespib

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

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