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Integrin beta 3 Antibody / ITGB3 / CD61

SKU: orb2643445

Description

Reacts with human integrin beta3 (GPIIIa, vitronectin receptor beta chain). It associates with the IIb-chain (CD41) to form the GpIIb/GpIIIa complex (CD41/CD61).The CD41/CD61 complex appears early in megakaryocyte maturation. The activated CD41/CD61 complex is a receptor for von Willebrand factor, soluble fibrinogen, fibronectin, vitronectin and thrombospondin. It plays a central role in platelet activation and aggregation. The CD51/CD61 is implicated in tumor metastasis and adenoviral infection. The antibody detects platelets in smears of blood and bone marrow, as well as megakaryocytes in frozen sections and cell smears. The antibody is useful for classification of megakaryoblastic leukemia.

Images & Validation

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Tested ApplicationsIHC-P
Dilution RangeImmunohistochemistry (FFPE): 1-2ug/ml
ReactivityHuman
Application Notes
Optimal dilution of the antibody should be determined by the researcher.

Key Properties

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Antibody TypePrimary Antibody
HostMouse
ClonalityMonoclonal
IsotypeMouse IgG2b, kappa
Clone No.ITGB3/2145
ImmunogenA recombinant human partial protein (amino acids 385-490) was used as the immunogen for this ITGB3 antibody.
PurityProtein G affinity chromatography
ConjugationUnconjugated

Storage & Handling

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StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Buffer/Preservatives0.2 mg/ml with 0.1 mg/ml rAlbumin (US sourced), 0.05% sodium azide
Expiration Date12 months from date of receipt.
Hazard InformationThis ITGB3 antibody is available for research use only.
DisclaimerFor research use only

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UniProt Details

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No UniProt data available

Protocol Information

IHC-P
Immunohistochemistry Paraffin
View Protocol

Available Sizes

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100 μg
$ 780.00
Choose Conjugation or Carrier Free Version
Free Secondary Antibody (20 ul)0/0

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