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Integrin alpha E Antibody / CD103

SKU: orb606581

Description

This antibody recognizes a protein of 150kDa, identified as CD103, which is the alpha-E integrin subunit of the heterodimeric alpha-E-beta-7 integrin belonging to a small beta-7 integrin subfamily. CD103 is expressed on more than 95% of intraepithelial CD8+ cells and on 40% of mucosa-associated T cells, whereas less than 2% of resting blood lymphocytes are CD103-positive. In several malignant conditions, such as T-cell lymphomas and hairy cell leukemia (HCL), the cells express CD103. This antibody is an extremely useful addition to the IHC panel for the diagnosis of hairy cell leukemia (HCL).

Research Area

Product Categories/Products/Antibodies,Product Categories/Research Area,Product Categories/Products/Antibodies/Primary Antibodies,Epigenetics

Images & Validation

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Tested ApplicationsIHC-P
Dilution RangeImmunohistochemistry (FFPE): 1-2ug/ml for 30 min at RT
ReactivityHuman
Application Notes
Titering of the CD103 antibody may be required for optimal performance.

Key Properties

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Antibody TypePrimary Antibody
HostMouse
ClonalityMonoclonal
IsotypeMouse IgG2b, kappa
Clone No.ITGAE/2474
ImmunogenA portion of amino acids 775-855 from the human protein was used as the immunogen for the CD103 antibody.
PurityProtein G affinity chromatography
ConjugationUnconjugated

Storage & Handling

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StorageStore the CD103 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).
Buffer/Preservatives0.2 mg/ml in 1X PBS with 0.1 mg/ml rAlbumin (US sourced) and 0.05% sodium azide
Expiration Date12 months from date of receipt.
Hazard InformationThis CD103 antibody is available for research use only.
DisclaimerFor research use only

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UniProt Details

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No UniProt data available

Protocol Information

IHC-P
Immunohistochemistry Paraffin
View Protocol

Available Sizes

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20 μg
$ 410.00
Free Secondary Antibody (20 ul)0/0

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DispatchUsually dispatched within 5-10 working days
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