GFRAL/GFR alpha-like Protein, Human, Recombinant (His & Avi)

SKU: orb1959866

Description

GFR alpha -like (GDNF receptor-alpha-like) is a distant member of the GDNFR family of proteins. Mature human GFR alpha-like is a 376 amino acid (aa) type I transmembrane protein. It contains a 333 aa extracellular domain, a 20 aa transmembrane domain and a 23 aa cytoplasmic domain.GFRAL is a brainstem-restricted receptor for GDF15 which regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses. GFRAL/GFR alpha-like Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 40.7 kDa and the accession number is Q6UXV0.

Research Area

,Recombinant-Protein

Images & Validation

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Application Notes	Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.

Key Properties

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Expression System	HEK293 Cells
Biological Origin	Human
Biological Activity	GFR alpha -like (GDNF receptor-alpha-like) is a distant member of the GDNFR family of proteins. Mature human GFR alpha-like is a 376 amino acid (aa) type I transmembrane protein. It contains a 333 aa extracellular domain, a 20 aa transmembrane domain and a 23 aa cytoplasmic domain.GFRAL is a brainstem-restricted receptor for GDF15 which regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses. GFRAL/GFR alpha-like Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 40.7 kDa and the accession number is Q6UXV0.
Tag	C-His-Avi
Expression Region	Ser19-Glu351
MW	40.7 kDa (predicted). Due to glycosylation, the protein migrates to 48-62 kDa based on Tris-Bis PAGE result.
Purity	98.00%

Storage & Handling

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Storage	-20°C
Expiration Date	6 months from date of receipt.
Disclaimer	For research use only

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Quick Database Links

UniProt

Q6UXV0

UniProt Details

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No UniProt data available

Protocol Information

Protein Handling and Storage Guide

Protein Handling Guide

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