CBL0137 hydrochloride

SKU: orb1302919

Description

Research Area

Product Categories/Products/Small Molecules,NF-κB|||Apoptosis

Images & Validation

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Key Properties

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CAS Number	1197397-89-9
MW	372.88
Purity	99.35%
Formula	C₂₁H₂₅ClN₂O₂
SMILES	Cl.CC(C)NCCn1c2ccc(cc2c2cc(ccc12)C(C)=O)C(C)=O

Bioactivity

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Target IC50	NF-κB:0.47 μM(EC50)\|p53:0.37 μM(EC50)\|FACT:
In Vivo	METHODS: ApoE−/− mice were treated with CBL0137 hydrochloride (Curaxin-137 hydrochloride) (1 mg/kg, oral, for three weeks) to observe the effects of CBL0137 hydrochloride (Curaxin-137 hydrochloride) on the atherosclerosis mouse model and perform Western blot experiments. RESULTSCBL0137 hydrochloride (Curaxin-137 hydrochloride) can reduce the formation of atherosclerotic plaques in partially ligated carotid arteries;CBL0137 hydrochloride (Curaxin-137 hydrochloride) treatment downregulated the protein levels of p-YAP (Y357) and p-Src (Y416) in these arteries, as well as the inflammatory genes MCP-1 and VCAM-1.
In Vitro	METHODS: HUVECs and HAECs cell treated with CBL0137 hydrochloride (Curaxin-137 hydrochloride) (0, 1, 3, 10 μM, 24 h) were tested for cell viability using the CCK-8 assay kit. RESULTS CBL0137 hydrochloride (Curaxin-137 hydrochloride) above 1 μM reduced the survival rate of HUVECs and HAECs.
Cell Research	Effects of CBLC137 (2 μM for 24 hours) on cell cycle in tumor (HT1080, RCC45, MiaPaca) and normal cells (Wi38, NKE-hTERT) are examined using FACS analysis of propidium iodide-stained cells.
Animal Research	Animal Models: xenograft mouse models of cancer. Formulation: water. Dosages: 30 mg/kg. Administration: p.o.

Storage & Handling

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Storage	-20°C
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

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Compound Identifiers

PubChem CID

44519123 ↗

Key Properties

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No computed properties available.

Protocol Information

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CAS Number:	[1197397-89-9]
MW:	372.89
Formula:	C₂₁H₂₅CLN₂O₂

Purity:	> 98% (HPLC)
CAS Number:	1197397-89-9
MW:	372.9
Formula:	C₂₁H₂₅ClN₂O₂

CBL0137 hydrochloride

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

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