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Anti-Hu CD261 Purified

SKU: orb154377

Description

Mouse monoclonal antibody to CD261 which is a receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to activated CD261 which is expressed in most human tissues including spleen, peripheral blood leucocytes, thymus and in a variety oFT tumour-derived cell lines. It plays a role in inducing cell death. The binding oFT TRAIL to DR4 triggers the activation oFT pro-caspases 8 and 10, leading to apoptosis.

Research Area

Apoptotic, Cancer, Epigenetics, Neuroscience, Signaling Pathways

Images & Validation

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Tested ApplicationsFC, ICC, IP
ReactivityHuman
Application Notes
Flow cytometry: Recommended dilution: 1-4 μg/ml.

Key Properties

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Antibody TypePrimary Antibody
ClonalityMonoclonal
IsotypeMouse IgG1
Clone No.DR-4-02
ImmunogenFusion protein containing the extracellular part of TRAIL-R1 and the constant part of the heavy chain of the human IgG1.
TargetCD261
PurityPurified by protein-A affinity chromatography.
PurificationPurified by protein-A affinity chromatography.
ConjugationUnconjugated

Storage & Handling

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StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Buffer/PreservativesPhosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Concentration1 mg/ml
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

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Anti-DR4 antibody, anti-APO2 antibody, anti-TNFRSF10A antibody, anti-TRAILR1 antibody, anti-TRAIL-R1 antibody

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  • Anti-Hu CD261 Purified Low Endotoxin [orb154420]

    FA,  FC,  ICC,  IP

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    Monoclonal

    Unconjugated

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Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

UniProt Details

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No UniProt data available

NCBI Gene Details

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No NCBI Gene data available

Protocol Information

FC
Flow Cytometry
View Protocol
ICC
Immunocytochemistry
View Protocol
IP
Immunoprecipitation
View Protocol

Available Sizes

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0.1 mg
$ 350.00
Free Secondary Antibody (20 ul)0/0

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DispatchUsually dispatched within 5-10 working days weeks.
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